Hugo Spatz (2 September 1888 – 27 January 1969) was a German neuropathologist.
In 1937, he was appointed director of the Kaiser Wilhelm Institute for Brain Research. He was a member of the Nazi Party, and admitted to knowingly performing much of his controversial research on the brains of executed prisoners. Along with Julius Hallervorden, he is credited with the discovery of Hallervorden-Spatz syndrome (now, in light of revelations of his Nazi past, more commonly referred to as Pantothenate kinase-associated neurodegeneration). Hugo Spatz's Oberarzt (senior resident or attending physician), 1937-1939, Richard Lindenberg, became chief neuropathologist of the State of Maryland.