Ellinah Wamukoya, the first woman bishop in the Anglican Church of Africa, died after she was admitted to hospital for treatment for Covid-19.
Wamukoya was elected to the position in 2012.
She was the Bishop of eSwatini and a town planner in eSwatini.
In a statement, the Anglican Church of Southern Africa said Ellinah Wamukoya died after she was admitted to hospital late last week.
She had been put on oxygen therapy, but later died.
"We express our deepest condolences to her husband, Okwaro Henry Wamukoya, their children and grandchildren. May her soul rest in peace," said Archbishop Thabo Makgoba.
He said she used to be the town clerk of Manzini, and also held a Master's degree in Town and Regional Planning.
She was ordained as a priest in 2005 and at the time that she was elected bishop, she was elected the Anglican chaplain to the University of eSwatini.
She was the liaison bishop for the environment in the Province of Southern Africa. In 2016, she was named by the BBC in London as one of the world's 100 most inspirational and influential women.